INO80 Chromatin Remodeler Facilitates Release of RNA Polymerase II from Chromatin for Ubiquitin-Mediated Proteasomal Degradation

Stalling of RNA Polymerase II (RNAPII) on chromatin during transcriptional stress results in polyubiquitination and degradation of the largest subunit of RNAPII, Rpb1, by the ubiquitin proteasome system (UPS). Here, we report that the ATP-dependent chromatin remodeling complex INO80 is required for...

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Publié dans:Mol Cell
Auteurs principaux: Lafon, Anne, Taranum, Surayya, Pietrocola, Federico, Dingli, Florent, Loew, Damarys, Brahma, Sandipan, Bartholomew, Blaine, Papamichos-Chronakis, Manolis
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760348/
https://ncbi.nlm.nih.gov/pubmed/26656161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.028
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