Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis

Cancer-associated fibroblasts (CAFs) are a major cancer-promoting component in the tumor microenvironment (TME). The dynamic role of human CAFs in cancer progression has been ill-defined because human CAFs lack a unique marker needed for a cell-specific, promoter-driven knockout model. Here, we deve...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Shen, Keyue, Luk, Samantha, Elman, Jessica, Murray, Ryan, Mukundan, Shilpaa, Parekkadan, Biju
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759812/
https://ncbi.nlm.nih.gov/pubmed/26893143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21239
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