Modeling and predicting optimal treatment scheduling between the antiangiogenic drug sunitinib and irinotecan in preclinical settings

We present a system of nonlinear ordinary differential equations used to quantify the complex dynamics of the interactions between tumor growth, vasculature generation, and antiangiogenic treatment. The primary dataset consists of longitudinal tumor size measurements (1,371 total observations) in 10...

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Vydáno v:CPT Pharmacometrics Syst Pharmacol
Hlavní autoři: Wilson, S, Tod, M, Ouerdani, A, Emde, A, Yarden, Y, Adda Berkane, A, Kassour, S, Wei, MX, Freyer, G, You, B, Grenier, E, Ribba, B
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2015
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759705/
https://ncbi.nlm.nih.gov/pubmed/26904386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12045
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