Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease

We have sequenced the complete genomes of 72 individuals affected with early-onset familial Alzheimer's disease caused by an autosomal dominant, highly penetrant mutation in the presenilin-1 (PSEN1) gene, and performed genome-wide association testing to identify variants that modify age at onse...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Lalli, M A, Bettcher, B M, Arcila, M L, Garcia, G, Guzman, C, Madrigal, L, Ramirez, L, Acosta-Uribe, J, Baena, A, Wojta, K J, Coppola, G, Fitch, R, de Both, M D, Huentelman, M J, Reiman, E M, Brunkow, M E, Glusman, G, Roach, J C, Kao, A W, Lopera, F, Kosik, K S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Immediate Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759097/
https://ncbi.nlm.nih.gov/pubmed/26324103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.131
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