M. tuberculosis T cell epitope analysis reveals paucity of antigenic variation and identifies rare variable TB antigens

Pathogens that evade adaptive immunity typically exhibit antigenic variation. By contrast, it appears that although the chronic human tuberculosis (TB)-causing pathogen Mycobacterium tuberculosis needs to counter host T cell responses, its T cell epitopes are hyperconserved. Here we present an exten...

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Bibliographic Details
Published in:Cell Host Microbe
Main Authors: Coscolla, Mireia, Copin, Richard, Sutherland, Jayne, Gehre, Florian, de Jong, Bouke, Owolabi, Olumuiya, Mbayo, Georgetta, Giardina, Federica, Ernst, Joel D., Gagneux, Sebastien
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758912/
https://ncbi.nlm.nih.gov/pubmed/26607161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.10.008
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