Lifestyle Intervention for Weight Loss and Cardiometabolic Changes in the Setting of Glucokinase Regulatory Protein (GCKR) Inhibition: GCKR-Leu446Pro Variant in Look AHEAD

BACKGROUND: Glucokinase regulatory protein (GCKR) inhibitors offer a novel treatment approach for glucose control in diabetes; however their cardiometabolic effects, particularly in relation to increased triglycerides and C-reactive protein (CRP) levels are of concern. GCKR Leu446Pro is a common var...

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發表在:Circ Cardiovasc Genet
Main Authors: Belalcazar, L. Maria, Papandonatos, George D., Erar, Bahar, Peter, Inga, Alkofide, Hadeel, Balasubramanyam, Ashok, Brautbar, Ariel, Kahn, Steven E., Knowler, William C., Ballantyne, Christie M., McCaffery, Jeanne M., Huggins, Gordon S.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758870/
https://ncbi.nlm.nih.gov/pubmed/26578543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.115.001192
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