Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance

Fifth-generation cephalosporins, ceftobiprole and ceftaroline, are promising drugs for treatment of bacterial infections from methicillin-resistant Staphylococcus aureus (MRSA). These antibiotics are able to bind native PBP2a, the penicillin-binding protein encoded by the mecA resistance determinant...

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Bibliographic Details
Published in:PLoS One
Main Authors: Greninger, Alexander L., Chatterjee, Som S., Chan, Liana C., Hamilton, Stephanie M., Chambers, Henry F., Chiu, Charles Y.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758708/
https://ncbi.nlm.nih.gov/pubmed/26890675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149541
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