mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination

Thymus is crucial for generation of a diverse repertoire of T cells essential for adaptive immunity. Although thymic epithelial cells (TECs) are crucial for thymopoiesis and T cell generation, how TEC development and function are controlled is poorly understood. We report here that mTOR complex 1 (m...

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Veröffentlicht in:PLoS Biol
Hauptverfasser: Wang, Hong-Xia, Shin, Jinwook, Wang, Shang, Gorentla, Balachandra, Lin, Xingguang, Gao, Jimin, Qiu, Yu-Rong, Zhong, Xiao-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758703/
https://ncbi.nlm.nih.gov/pubmed/26889835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002370
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