Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line

Eukaryotic translation initiation factor 4E (eIF4E) was shown to be upregulated in malignant human tumors. To assess the effect of downregulation of eIF4E on the proliferation and invasiveness of a human lung adenocarcinoma cell line, a short hairpin (sh)RNA targeting eIF4E was constructed and trans...

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Publicado no:Mol Med Rep
Principais autores: CHEN, BAOFU, ZHANG, BO, XIA, LILONG, ZHANG, JIAN, CHEN, YU, HU, QUANTENG, ZHU, CHENGCHU
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758288/
https://ncbi.nlm.nih.gov/pubmed/26498338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2015.4468
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