A ROS-Activatable Agent Elicits Homologous Recombination DNA Repair and Synergizes with Pathway Compounds

We designed ROS-activated cytotoxic agents (RACs) that are active against AML cancer cells. In this study, the mechanism of action and synergistic effects against cells coexpressing the AML oncogenes MLL-AF9 fusion and FLT3-ITD were investigated. One RAC (RAC1) had an IC(50) value of 1.8 ± 0.3 µm, w...

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Détails bibliographiques
Publié dans:Chembiochem
Auteurs principaux: Thowfeik, Fathima Shazna, AbdulSalam, Safnas F., Wunderlich, Mark, Wyder, Michael, Greis, Kenneth D., Kadekaro, Ana L., Mulloy, James C., Merino, Edward J.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758217/
https://ncbi.nlm.nih.gov/pubmed/26419938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500304
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