Microwave gallium-68 radiochemistry for kinetically stable bis(thiosemicarbazone) complexes: structural investigations and cellular uptake under hypoxia

We report the microwave synthesis of several bis(thiosemicarbazones) and the rapid gallium-68 incorporation to give the corresponding metal complexes. These proved kinetically stable under ‘cold’ and ‘hot’ biological assays and were investigated using laser scanning confocal microscopy, flow cytomet...

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Dettagli Bibliografici
Pubblicato in:Dalton Trans
Autori principali: Alam, Israt S., Arrowsmith, Rory L., Cortezon-Tamarit, Fernando, Twyman, Frazer, Kociok-Köhn, Gabriele, Botchway, Stanley W., Dilworth, Jonathan R., Carroll, Laurence, Aboagye, Eric O., Pascu, Sofia I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2016
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758186/
https://ncbi.nlm.nih.gov/pubmed/26583314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5dt02537k
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