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Subgroup analyses in confirmatory clinical trials: time to be specific about their purposes

BACKGROUND: It is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental step in the assessment of evidence from confirmatory (Phase III) clinical trials, where conclusions for the overall study population might not hold....

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Detalhes bibliográficos
Publicado no:BMC Med Res Methodol
Main Authors: Tanniou, Julien, van der Tweel, Ingeborg, Teerenstra, Steven, Roes, Kit C. B.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757983/
https://ncbi.nlm.nih.gov/pubmed/26891992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-016-0122-6
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