Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance and a systemic pro-inflammatory response. Here we show that tumour necrosis factor receptor-associated factor 3 (TRAF3) is upregulated in mouse and human livers with hepatic steatosis. After 24 weeks...

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Pubblicato in:Nat Commun
Autori principali: Wang, Pi-Xiao, Zhang, Xiao-Jing, Luo, Pengcheng, Jiang, Xi, Zhang, Peng, Guo, Junhong, Zhao, Guang-Nian, Zhu, Xueyong, Zhang, Yan, Yang, Sijun, Li, Hongliang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757796/
https://ncbi.nlm.nih.gov/pubmed/26882989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10592
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