Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway

Brain development requires a fine-tuned copper homoeostasis. Copper deficiency or excess results in severe neuro-pathologies. We demonstrate that upon neuronal differentiation, cellular demand for copper increases, especially within the secretory pathway. Copper flow to this compartment is facilitat...

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Udgivet i:Nat Commun
Main Authors: Hatori, Yuta, Yan, Ye, Schmidt, Katharina, Furukawa, Eri, Hasan, Nesrin M., Yang, Nan, Liu, Chin-Nung, Sockanathan, Shanthini, Lutsenko, Svetlana
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757759/
https://ncbi.nlm.nih.gov/pubmed/26879543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10640
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