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Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway
Brain development requires a fine-tuned copper homoeostasis. Copper deficiency or excess results in severe neuro-pathologies. We demonstrate that upon neuronal differentiation, cellular demand for copper increases, especially within the secretory pathway. Copper flow to this compartment is facilitat...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4757759/ https://ncbi.nlm.nih.gov/pubmed/26879543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10640 |
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