Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01

The ability of Tetra-O-methyl nordihydroguaiaretic acid (M(4)N) to induce rapid cell death in combination with Etoposide, Rapamycin, or UCN-01 was examined in LNCaP cells, both in cell culture and animal experiments. Mice treated with M(4)N drug combinations with either Etoposide or Rapamycin showed...

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Publicat a:PLoS One
Autors principals: Kimura, Kotohiko, Huang, Ru Chih C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757551/
https://ncbi.nlm.nih.gov/pubmed/26886430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148685
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