Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice

BACKGROUND: Thelper1 (Th1) lymphocytes have been previously implicated in atherosclerotic plaque growth but their role in plaque vulnerability to rupture is less clear. We investigated whether T-bet knockout that prevents Th1 lymphocyte differentiation modulates classical (M1) macrophage activation...

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Publicado en:PLoS One
Autores principales: Tsaousi, Aikaterini, Hayes, Elaine M., Di Gregoli, Karina, Bond, Andrew R., Bevan, Laura, Thomas, Anita C., Newby, Andrew C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757422/
https://ncbi.nlm.nih.gov/pubmed/26886778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148873
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