Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria

Protochordate variable region-containing chitin-binding proteins (VCBPs) consist of immunoglobulin-type V domains and a chitin-binding domain (CBD). VCBP V domains facilitate phagocytosis of bacteria by granulocytic amoebocytes; the function of the CBD is not understood. Here we show that the gut mu...

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Udgivet i:Nat Commun
Main Authors: Dishaw, Larry J., Leigh, Brittany, Cannon, John P., Liberti, Assunta, Mueller, M. Gail, Skapura, Diana P., Karrer, Charlotte R., Pinto, Maria R., De Santis, Rosaria, Litman, Gary W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757023/
https://ncbi.nlm.nih.gov/pubmed/26875669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10617
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