Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity

Autoantibodies to nuclear antigens arise in human autoimmune diseases, but a unifying pathogenetic mechanism remains elusive. Recently we reported that exposure of neutrophils to inflammatory conditions induces the citrullination of core histones by peptidylarginine deiminase 4 (PAD4) and that patie...

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Udgivet i:FASEB J
Main Authors: Dwivedi, Nishant, Neeli, Indira, Schall, Nicolas, Wan, Haibao, Desiderio, Dominic M., Csernok, Elena, Thompson, Paul R., Dali, Hayet, Briand, Jean-Paul, Muller, Sylviane, Radic, Marko
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2014
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756806/
https://ncbi.nlm.nih.gov/pubmed/24671707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-247254
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