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The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein G(o)
Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a sign-inverting cascade. Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the heterotrimeric G-protein Gα(o)β3γ13, and this leads to closure of the TRPM1 channel (melastatin). TRPM1 i...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4756708/ https://ncbi.nlm.nih.gov/pubmed/26883481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20940 |
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