The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein G(o)

Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a sign-inverting cascade. Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the heterotrimeric G-protein Gα(o)β3γ13, and this leads to closure of the TRPM1 channel (melastatin). TRPM1 i...

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Vydáno v:Sci Rep
Hlavní autoři: Xu, Ying, Orlandi, Cesare, Cao, Yan, Yang, Shengyan, Choi, Chan-Il, Pagadala, Vijayakanth, Birnbaumer, Lutz, Martemyanov, Kirill A., Vardi, Noga
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756708/
https://ncbi.nlm.nih.gov/pubmed/26883481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20940
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