Crizotinib Synergizes with Chemotherapy in Preclinical Models of Neuroblastoma

PURPOSE: The presence of an ALK aberration correlates with inferior survival for patients with high-risk neuroblastoma. The emergence of ALK inhibitors such as crizotinib has provided novel treatment opportunities. However, certain ALK mutations result in de novo crizotinib resistance, and a phase I...

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Udgivet i:Clin Cancer Res
Main Authors: Krytska, Kateryna, Ryles, Hannah T., Sano, Renata, Raman, Pichai, Infarinato, Nicole R., Hansel, Theodore D., Makena, Monish R., Song, Michael M., Reynolds, C. Patrick, Mossé, Yael P.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755925/
https://ncbi.nlm.nih.gov/pubmed/26438783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0379
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