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G-protein-gated inwardly rectifying potassium channels modulate respiratory depression by opioids
BACKGROUND: Drugs acting on μ-opioid receptors (MOR) are widely used as analgesics, but present side-effects including life-threatening respiratory depression. MOR are G-protein-coupled receptors inhibiting neuronal activity through calcium channels, adenylyl cyclase, and/or G-protein–gated inwardly...
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| Published in: | Anesthesiology |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4755838/ https://ncbi.nlm.nih.gov/pubmed/26675532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000984 |
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