Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis

The Jagn1 protein was indentified in a SILAC proteomic screen of proteins that are increased in insulinoma cells expressing a folding-deficient proinsulin. Jagn1 mRNA was detected in primary rodent islets and in insulinoma cell lines and the levels were increased in response to ER stress. The functi...

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Veröffentlicht in:PLoS One
Hauptverfasser: Nosak, Courtney, Silva, Pamuditha N., Sollazzo, Pietro, Moon, Kyung-Mee, Odisho, Tanya, Foster, Leonard J., Rocheleau, Jonathan V., Volchuk, Allen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755616/
https://ncbi.nlm.nih.gov/pubmed/26882284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149177
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