Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis

The Jagn1 protein was indentified in a SILAC proteomic screen of proteins that are increased in insulinoma cells expressing a folding-deficient proinsulin. Jagn1 mRNA was detected in primary rodent islets and in insulinoma cell lines and the levels were increased in response to ER stress. The functi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Nosak, Courtney, Silva, Pamuditha N., Sollazzo, Pietro, Moon, Kyung-Mee, Odisho, Tanya, Foster, Leonard J., Rocheleau, Jonathan V., Volchuk, Allen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755616/
https://ncbi.nlm.nih.gov/pubmed/26882284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149177
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