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Precision of maximum likelihood estimation in adaptive designs

There has been increasing interest in trials that allow for design adaptations like sample size reassessment or treatment selection at an interim analysis. Ignoring the adaptive and multiplicity issues in such designs leads to an inflation of the type 1 error rate, and treatment effect estimates bas...

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Bibliografiske detaljer
Udgivet i:Stat Med
Main Authors: Graf, Alexandra Christine, Gutjahr, Georg, Brannath, Werner
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755201/
https://ncbi.nlm.nih.gov/pubmed/26459506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.6761
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