Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia

BACKGROUND: Epigenetic regulators play a critical role in the maintenance of specific chromatin domains in an active or repressed state. Disruption of epigenetic regulatory mechanisms is widespread in cancer cells and largely contributes to the transformation process through active repression of tum...

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發表在:Mol Cancer
Main Authors: Yeh, Chien-Hung, Bai, Xue Tao, Moles, Ramona, Ratner, Lee, Waldmann, Thomas A., Toshiki, Watanabe, Nicot, Christophe
格式: Artigo
語言:Inglês
出版: BioMed Central 2016
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754821/
https://ncbi.nlm.nih.gov/pubmed/26880370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0500-z
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