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Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-κB and NFATc1 activation and DC-STAMP expression

AIM: Aconiti Lateralis Radix Preparata is a traditional Chinese medicine used to treat chronic arthritis and is highly effective against rheumatoid arthritis. However, the effects of aconine, a derivative of aconitum alkaloids, on osteoclasts, which can absorb bone, remain unknown. Here, we investig...

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Bibliografiske detaljer
Udgivet i:Acta Pharmacol Sin
Main Authors: Zeng, Xiang-zhou, He, Long-gang, Wang, Song, Wang, Keng, Zhang, Yue-yang, Tao, Lei, Li, Xiao-juan, Liu, Shu-wen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753374/
https://ncbi.nlm.nih.gov/pubmed/26592521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.85
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