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Molecularly targeted therapy for advanced hepatocellular carcinoma - a drug development crisis?

Hepatocellular carcinoma is the fastest growing cause of cancer related death globally. Sorafenib, a multi-targeted kinase inhibitor, is the only drug proven to improve outcomes in patients with advanced disease offering modest survival benefit. Although comprehensive genomic mapping has improved un...

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Bibliografske podrobnosti
izdano v:World J Gastrointest Oncol
Main Authors: Thillai, Kiruthikah, Ross, Paul, Sarker, Debashis
Format: Artigo
Jezik:Inglês
Izdano: Baishideng Publishing Group Inc 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753168/
https://ncbi.nlm.nih.gov/pubmed/26909132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4251/wjgo.v8.i2.173
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