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Biochemical and spectroscopic studies of epoxyqueuosine reductase: A novel iron-sulfur cluster and cobalamin containing protein involved in the biosynthesis of queuosine

Queuosine is a hypermodified nucleoside present in the wobble position of tRNAs with a 5′-GUN-3′ sequence in their anticodon (His, Asp, Asn, and Tyr). The 7-deazapurine core of the base is synthesized de novo in prokaryotes from guanosine-5′-triphosphate in a series of eight sequential enzymatic tra...

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Publicat a:Biochemistry
Autors principals: Miles, Zachary D., Myers, William K., Kincannon, William M., Britt, R. David, Bandarian, Vahe
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753064/
https://ncbi.nlm.nih.gov/pubmed/26230193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00335
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