Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses

The live attenuated yellow fever virus (YFV) vaccine 17D stands as a “gold standard” for a successful vaccine. 17D was developed empirically by passaging the wild-type Asibi strain in mouse and chicken embryo tissues. Despite its immense success, the molecular determinants for virulence attenuation...

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Pubblicato in:mBio
Autori principali: Fernandez-Garcia, Maria Dolores, Meertens, Laurent, Chazal, Maxime, Hafirassou, Mohamed Lamine, Dejarnac, Ophélie, Zamborlini, Alessia, Despres, Philippe, Sauvonnet, Nathalie, Arenzana-Seisdedos, Fernando, Jouvenet, Nolwenn, Amara, Ali
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Microbiology 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752603/
https://ncbi.nlm.nih.gov/pubmed/26861019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01956-15
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