Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles

Neisseria meningitidis recruits host human complement inhibitors to its surface to down-regulate complement activation and enhance survival in blood. We have investigated whether such complement inhibitor binding occurs after vaccination with native outer membrane vesicles (nOMVs), and limits immuno...

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Veröffentlicht in:PLoS One
Hauptverfasser: Daniels-Treffandier, Helene, de Nie, Karlijn, Marsay, Leanne, Dold, Christina, Sadarangani, Manish, Reyes-Sandoval, Arturo, Langford, Paul R., Wyllie, David, Hill, Fergal, Pollard, Andrew J., Rollier, Christine S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752311/
https://ncbi.nlm.nih.gov/pubmed/26871712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148840
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