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Structural and Functional Characterization of a Caenorhabditis elegans Genetic Interaction Network within Pathways

A genetic interaction (GI) is defined when the mutation of one gene modifies the phenotypic expression associated with the mutation of a second gene. Genome-wide efforts to map GIs in yeast revealed structural and functional properties of a GI network. This provided insights into the mechanisms unde...

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Veröffentlicht in:PLoS Comput Biol
Hauptverfasser: Boucher, Benjamin, Lee, Anna Y., Hallett, Michael, Jenna, Sarah
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752231/
https://ncbi.nlm.nih.gov/pubmed/26871911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004738
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