Length-Dependent Formation of Transmembrane Pores by 3(10)-Helical α-Aminoisobutyric Acid Foldamers

[Image: see text] The synthetic biology toolbox lacks extendable and conformationally controllable yet easy-to-synthesize building blocks that are long enough to span membranes. To meet this need, an iterative synthesis of α-aminoisobutyric acid (Aib) oligomers was used to create a library of homolo...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Jones, Jennifer E., Diemer, Vincent, Adam, Catherine, Raftery, James, Ruscoe, Rebecca E., Sengel, Jason T., Wallace, Mark I., Bader, Antoine, Cockroft, Scott L., Clayden, Jonathan, Webb, Simon J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752191/
https://ncbi.nlm.nih.gov/pubmed/26699898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b12057
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