Is duloxetine's effect on painful physical symptoms in depression an indirect result of improvement of depressive symptoms? Pooled analyses of three randomized controlled trials

In treating Major Depressive Disorder with associated painful physical symptoms (PPS), the effect of duloxetine on PPS has been shown to decompose into a direct effect on PPS and an indirect effect on PPS via depressive symptoms (DS) improvement. To evaluate the changes in relative contributions of...

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Vydáno v:Pain
Hlavní autoři: Harada, Eiji, Tokuoka, Hirofumi, Fujikoshi, Shinji, Funai, Jumpei, Wohlreich, Madelaine M., Ossipov, Michael H., Iwata, Nakao
Médium: Artigo
Jazyk:Inglês
Vydáno: Wolters Kluwer 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751744/
https://ncbi.nlm.nih.gov/pubmed/26882344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000406
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