Does VEGF facilitate local tumor growth and spread into the abdominal cavity by suppressing endothelial cell adhesion, thus increasing vascular peritoneal permeability followed by ascites production in ovarian cancer?

BACKGROUND: Ovarian cancer is mostly associated with pathologically regulated permeability of peritoneal vessels, leading to ascites. Here, we investigated the molecular regulation of endothelial permeability by the vascular endothelial growth factor (VEGF) and both tight and adherens junction prote...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Bekes, Inga, Friedl, Thomas W. P., Köhler, Tanja, Möbus, Volker, Janni, Wolfgang, Wöckel, Achim, Wulff, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751711/
https://ncbi.nlm.nih.gov/pubmed/26868378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0497-3
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