Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors

Early life diet can critically program hypothalamic-pituitary-adrenal (HPA) axis function. We have previously shown rats that are overfed as neonates have exacerbated pro-inflammatory responses to immune challenge with lipopolysaccharide (LPS), in part by altering HPA axis responses, but how this oc...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Cai, Guohui, Ziko, Ilvana, Barwood, Joanne, Soch, Alita, Sominsky, Luba, Molero, Juan C., Spencer, Sarah J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751608/
https://ncbi.nlm.nih.gov/pubmed/26868281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21097
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