Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase

The intracellular infections of Mycobacterium tuberculosis, which is the causative agent of tuberculosis, are regulated by many cyclic dinucleotide signaling. Rv2837c from M. tuberculosis is a soluble, stand-alone DHH-DHHA1 domain phosphodiesterase that down-regulates c-di-AMP through catalytic degr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: He, Qing, Wang, Feng, Liu, Shiheng, Zhu, Deyu, Cong, Hengjiang, Gao, Fei, Li, Bingqing, Wang, Hongwei, Lin, Zong, Liao, Jun, Gu, Lichuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751404/
https://ncbi.nlm.nih.gov/pubmed/26668313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.699801
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