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The Molecular Basis of TnrA Control by Glutamine Synthetase in Bacillus subtilis

TnrA is a master regulator of nitrogen assimilation in Bacillus subtilis. This study focuses on the mechanism of how glutamine synthetase (GS) inhibits TnrA function in response to key metabolites ATP, AMP, glutamine, and glutamate. We suggest a model of two mutually exclusive GS conformations gover...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hauf, Ksenia, Kayumov, Airat, Gloge, Felix, Forchhammer, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751389/
https://ncbi.nlm.nih.gov/pubmed/26635369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.680991
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