Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts

Osteoclasts are specialized polyploid cells that resorb bone. Upon stimulation with receptor activator of nuclear factor-κB ligand (RANKL), myeloid precursors commit to becoming polyploid, largely via cell fusion. Polyploidization of osteoclasts is necessary for their bone-resorbing activity, but th...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Takegahara, Noriko, Kim, Hyunsoo, Mizuno, Hiroki, Sakaue-Sawano, Asako, Miyawaki, Atsushi, Tomura, Michio, Kanagawa, Osami, Ishii, Masaru, Choi, Yongwon
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751386/
https://ncbi.nlm.nih.gov/pubmed/26670608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677427
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