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The Cholestanol-Conjugated Sulfated Oligosaccharide PG545 Disrupts the Lipid Envelope of Herpes Simplex Virus Particles

Herpes simplex virus (HSV) and many other viruses, including HIV, initiate infection of host cells by binding to glycosaminoglycan (GAG) chains of cell surface proteoglycans. Although GAG mimetics, such as sulfated oligo- and polysaccharides, exhibit potent antiviral activities in cultured cells, th...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Said, Joanna S., Trybala, Edward, Görander, Staffan, Ekblad, Maria, Liljeqvist, Jan-Åke, Jennische, Eva, Lange, Stefan, Bergström, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750709/
https://ncbi.nlm.nih.gov/pubmed/26643323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02132-15
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