Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data

We confirmed strong association of rs78378222:A>C (per allele odds ratio [OR] = 3.14; P = 6.48 × 10(−11)), a germline rare single-nucleotide polymorphism (SNP) in TP53, via imputation of a genome-wide association study of glioma (1,856 cases and 4,955 controls). We subsequently performed integrat...

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Udgivet i:Hum Mutat
Main Authors: Wang, Zhaoming, Rajaraman, Preetha, Melin, Beatrice S., Chung, Charles C., Zhang, Weijia, McKean-Cowdin, Roberta, Michaud, Dominique, Yeager, Meredith, Ahlbom, Anders, Albanes, Demetrius, Andersson, Ulrika, Beane Freeman, Laura E., Buring, Julie E., Butler, Mary Ann, Carreón, Tania, Feychting, Maria, Gapstur, Susan M., Gaziano, J. Michael, Giles, Graham G., Hallmans, Goran, Henriksson, Roger, Hoffman-Bolton, Judith, Inskip, Peter D., Kitahara, Cari M., Le Marchand, Loic, Linet, Martha S., Li, Shengchao, Peters, Ulrike, Purdue, Mark P., Rothman, Nathaniel, Ruder, Avima M., Sesso, Howard D., Severi, Gianluca, Stampfer, Meir, Stevens, Victoria L., Visvanathan, Kala, Wang, Sophia S., White, Emily, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Fraumeni, Joseph F., Chatterjee, Nilanjan, Hartge, Patricia, Chanock, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750473/
https://ncbi.nlm.nih.gov/pubmed/25907361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22799
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