Effects of FVIII immunity on hepatocyte and hematopoietic stem cell–directed gene therapy of murine hemophilia A

Immune responses to coagulation factors VIII (FVIII) and IX (FIX) represent primary obstacles to hemophilia treatment. Previously, we showed that hematopoietic stem cell (HSC) retroviral gene therapy induces immune nonresponsiveness to FVIII in both naive and preimmunized murine hemophilia A setting...

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Détails bibliographiques
Publié dans:Mol Ther Methods Clin Dev
Auteurs principaux: Lytle, Allison M, Brown, Harrison C, Paik, Na Yoon, Knight, Kristopher A, Wright, J Fraser, Spencer, H Trent, Doering, Christopher B
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750467/
https://ncbi.nlm.nih.gov/pubmed/26909355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.56
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