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Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain

CONTEXT: Delivery of drugs from the nasal cavity to the brain is becoming more widely accepted, due to the non-invasive nature of this route and the ability to circumvent the blood brain barrier (BBB). OBJECTIVE: Because of similarities in the proteins comprising the olfactory epithelial tight junct...

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Detalhes bibliográficos
Publicado no:Drug Deliv
Main Authors: Krishan, Mansi, Gudelsky, Gary A., Desai, Pankaj B., Genter, Mary Beth
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750388/
https://ncbi.nlm.nih.gov/pubmed/24116937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10717544.2013.840017
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