Digital Sorting of Pure Cell Populations Enables Unambiguous Genetic Analysis of Heterogeneous Formalin-Fixed Paraffin-Embedded Tumors by Next Generation Sequencing

Precision medicine in oncology requires an accurate characterization of a tumor molecular profile for patient stratification. Though targeted deep sequencing is an effective tool to detect the presence of somatic sequence variants, a significant number of patient specimens do not meet the requiremen...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Bolognesi, Chiara, Forcato, Claudio, Buson, Genny, Fontana, Francesca, Mangano, Chiara, Doffini, Anna, Sero, Valeria, Lanzellotto, Rossana, Signorini, Giulio, Calanca, Alex, Sergio, Maximilian, Romano, Rita, Gianni, Stefano, Medoro, Gianni, Giorgini, Giuseppe, Morreau, Hans, Barberis, Massimo, Corver, Willem E., Manaresi, Nicolò
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750064/
https://ncbi.nlm.nih.gov/pubmed/26864208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20944
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