Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells

Aberrant NOTCH1 signalling is critically involved in multiple models of colorectal cancer (CRC) and a prominent role of NOTCH1 activity during inflammation has emerged. Epithelial to Mesenchymal Transition (EMT), a crucial event promoting malignant transformation, is regulated by inflammation and Me...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fazio, Chiara, Piazzi, Giulia, Vitaglione, Paola, Fogliano, Vincenzo, Munarini, Alessandra, Prossomariti, Anna, Milazzo, Maddalena, D’Angelo, Leonarda, Napolitano, Manuela, Chieco, Pasquale, Belluzzi, Andrea, Bazzoli, Franco, Ricciardiello, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749954/
https://ncbi.nlm.nih.gov/pubmed/26864323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20670
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