A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

A new mutant mouse (lamb1t) exhibits intermittent dystonic hindlimb movements and postures when awake, and hyperextension when asleep. Experiments showed co-contraction of opposing muscle groups, and indicated that symptoms depended on the interaction of brain and spinal cord. SNP mapping and exome...

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Foilsithe in:eLife
Main Authors: Liu, Yi Bessie, Tewari, Ambika, Salameh, Johnny, Arystarkhova, Elena, Hampton, Thomas G, Brashear, Allison, Ozelius, Laurie J, Khodakhah, Kamran, Sweadner, Kathleen J
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2015
Ábhair:
Neuroscience
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749547/
https://ncbi.nlm.nih.gov/pubmed/26705335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11102
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