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Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and Autophagy as a Mechanism of Action

BACKGROUND: The treatment for leishmaniasis is currently based on pentavalent antimonials and amphotericin B; however, these drugs result in numerous adverse side effects. The lack of affordable therapy has necessitated the urgent development of new drugs that are efficacious, safe, and more accessi...

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Publicat a:PLoS Negl Trop Dis
Autors principals: Fonseca-Silva, Fernanda, Inacio, Job D. F., Canto-Cavalheiro, Marilene M., Menna-Barreto, Rubem F. S., Almeida-Amaral, Elmo E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749305/
https://ncbi.nlm.nih.gov/pubmed/26862901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004442
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