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Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation

Reagents for detecting post-translational modifications in the context of their protein scaffold are powerful tools, but are challenging to develop for glycosylated epitopes. We describe a strategy for detecting protein-specific glycosylation through the use of cyclooctyne-aptamer conjugates. These...

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Podrobná bibliografie
Vydáno v:J Am Chem Soc
Hlavní autoři: Robinson, Peter V., de Almeida-Escobedo, Gabriela, de Groot, Amber E., McKechnie, Julia L., Bertozzi, Carolyn R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748840/
https://ncbi.nlm.nih.gov/pubmed/26280358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04279
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