UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold

We identified UHRF1 as a binding factor for DNA interstrand crosslink (ICL) lesions through affinity purification of ICL-recognition activities. UHRF1 is recruited to DNA lesions in vivo and binds directly to ICL-containing DNA. UHRF1-deficient cells display increased sensitivity to a variety of DNA...

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Publicado no:Cell Rep
Main Authors: Tian, Yanyan, Paramasivam, Manikandan, Ghosal, Gargi, Chen, Ding, Shen, Xi, huang, Yaling, Akhter, Shamima, Legerski, Randy, Chen, Junjie, Seidman, Michael M, Qin, Jun, Li, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748712/
https://ncbi.nlm.nih.gov/pubmed/25818288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.03.038
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