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Development and characterization of the α3β4α5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts

The α3β4α5 nAChR has been recently shown to be a useful target for smoking cessation pharmacotherapies. Herein, we report on the development and characterization of the α3β4α5 nicotinic receptor column by frontal displacement chromatography. The binding affinity of the nicotine and minor alkaloids f...

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Publicat a:J Chromatogr A
Autors principals: Ciesla, L., Okine, M., Rosenberg, A., Dossou, K.S.S., Toll, L., Wainer, I.W., Moaddel, R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748418/
https://ncbi.nlm.nih.gov/pubmed/26774122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2015.12.065
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